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  • 陈 卫.肠道菌群:膳食与健康研究的新视角[J].食品科学技术学报,2015,33(6):1-6.    [点击复制]
  • CHEN Wei.Gut Microbiota—A New Concern on Health Regulation[J].Journal of Food Science and Technology,2015,33(6):1-6.   [点击复制]
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肠道菌群:膳食与健康研究的新视角
陈卫
0
(江南大学 食品学院/食品科学与技术国家重点实验室, 江苏 无锡 214122)
摘要:
近年来,随着“人类微生物组计划”、“肠道元基因组计划”等研究项目的开展,人类对肠道菌群的关注达到了空前的高度。随着对其结构和功能的不断挖掘,人们发现肠道菌群与宿主健康密切相关,甚至被认为是“被忽略的人体器官”。最新的研究报道表明,包括帕金森病、乳腺癌、艾滋病、肝硬化、肾病、关节炎、糖尿病等在内的疾病都与肠道微生物结构异常相关;同时最近有很多研究从肠道菌群的角度关注了食品甜味剂、食品乳化剂、节食等因素对机体的影响;另外,肠道菌群也已成为我们阐释益生菌、益生元、微量元素、多酚化合物等膳食因子调控健康研究的着眼点。可以预见,随着肠道微生物研究方法和手段的不断发展,肠道菌群有可能成为多种疾病预测诊断的标志物;同时,许多人类疾病的发病机制及干预机制、食物保健功能等将有可能通过肠道微生态理论而得到更好地诠释和补充。
关键词:  肠道菌群  益生菌  健康调控  疾病  膳食因子
DOI:10.3969/j.issn.2095-6002.2015.06.001
投稿时间:2015-06-09
基金项目:国家杰出青年科学基金项目(31125012)。
Gut Microbiota—A New Concern on Health Regulation
CHEN Wei
(School of Food Science and Technology/State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China)
Abstract:
With the development of “Human Microbiome Project” and “Metagenomics of the Human Intestinal Tract”, great attention has been paid on human gut microbiota. With the increasing knowledge of the composition and function of gut microbiota, we found that gut microbiota play an important role on human health, and can be regarded as “the forgotten organ”. The recent researches have showed that diseases such as Parkinson's disease, breast cancer, HIV, hepatic cirrhosis, renal disorder, arthrophlogosis, diabetes are related to the dysfunction of gut microbiota. Several studies also revealed the effects of sweetening agents, emulsifying agents and diet on health by concerning the role of gut microbiota. Moreover, gut microbiota have become a new point of view for the investigation on the beneficial mechanism of dietary factors including probiotics, prebiotics, essential elements, and polyphenols. With the development of related researches, gut microbiota may become the biomarkers for the prediction and diagnosis of diseases. The pathogenesis and protective mechanisms of diseases and healthy food respectively can also be better explained by evaluating the effects of gut microbiota on human health.
Key words:  gut microbiota  probiotics  health regulation  disease  dietary factors