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  • 魏杰,张潇,张国坤,万冬梅,林景峰,孙淑华.红菇多糖对小鼠肝脏衰老的抑制效果[J].食品科学技术学报,2017,35(3):50-54.    [点击复制]
  • WEI Jie,ZHANG Xiao,ZHANG Guokun,WAN Dongmei,LIU Jingfeng,SUN Shuhua.Inhibitory Effect of Russula farinipes Romell Polysaccharide on Mice Liver Senescence[J].Journal of Food Science and Technology,2017,35(3):50-54.   [点击复制]
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红菇多糖对小鼠肝脏衰老的抑制效果
魏杰,张潇,张国坤,万冬梅,林景峰,孙淑华
0
(辽宁大学 生命科学院, 辽宁 沈阳 110036;辽宁仙人洞国家级自然保护区管理局, 辽宁 大连 116407)
摘要:
研究红菇多糖对衰老昆明小鼠肝功能衰退的抑制作用。使用D-半乳糖建立衰老模型,并在此期间给予75mg/L与150mg/L红菇多糖饮水。8周后断颈处死,检测肝指数、血清和肝组织的谷胱甘肽过氧化物酶、超氧化物歧化酶活性及丙二醛含量,同时对肝组织Ca2+-ATPase活性及形态学进行分析。结果表明,8周内给予红菇多糖150mg/L饮水时,小鼠肝指数、谷胱甘肽过氧化物酶、超氧化物歧化酶活性得到显著提高,丙二醛含量显著下降,小鼠肝功能衰退得到了显著抑制(p<0.05),肝脏的衰老及损伤也得到了有效抵制。
关键词:  红菇多糖  肝脏  抗衰老
DOI:10.3969/j.issn.2095-6002.2017.03.007
投稿时间:2016-09-21
基金项目:辽宁仙人洞国家级自然保护区大型真菌资源调查项目; 辽宁省教育厅教学研究项目(LYB201611); 辽宁省社会科学规划基金资助项目(L15BJY029)。
Inhibitory Effect of Russula farinipes Romell Polysaccharide on Mice Liver Senescence
WEI Jie,ZHANG Xiao,ZHANG Guokun,WAN Dongmei,LIU Jingfeng,SUN Shuhua
(School of Life Science, Liaoning University, Shenyang 110036, China;Liaoning Xianrendong National Nature Reserve Administration Bureau, Dalian 116407, China)
Abstract:
Effects of Russula polysaccharide on mice hepatic insufficiency were investigated in this study. The senile model mice were established by D-galactose and mice were treated by 75mg/L and 150mg/L Russula polysaccharide. After 8 weeks, liver index, serum and hepatic GSH-Px, SOD activity, MDA contents, Ca2+-ATPase activity and hematoxylin-eosin staining of mice were determined. The results showed that the treatment of 150mg/L Russula polysaccharide could increase liver index, GSH-Px and SOD activity, and decrease the MDA content, which could inhibit the aging of liver.
Key words:  Russula polysaccharide  liver  anti-aging