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  • 姜绍通,李兴江.苹果酸生物炼制研究进展[J].食品科学技术学报,2019,37(2):1-9.    [点击复制]
  • JIANG Shaotong,LI Xingjiang.Progress for Bio-Refinery of Malic Acid[J].Journal of Food Science and Technology,2019,37(2):1-9.   [点击复制]
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苹果酸生物炼制研究进展
姜绍通,李兴江
0
(安徽省农产品精深加工重点实验室/合肥工业大学 食品与生物工程学院, 安徽 合肥 230009)
摘要:
苹果酸作为最重要的四碳二元羧酸,广泛应用于食品、化工及医药等领域,利用生物炼制手段转化可再生糖制备苹果酸具有重要意义。介绍和总结了苹果酸生物炼制流程,即发酵原料经接种菌种后,分析其主要代谢途径,寻找产苹果酸的关键酶,确定苹果酸代谢改善策略,从而通过控制关键酶和关键因子的合成或代谢优化发酵工艺,提高苹果酸产量;在进行技术总结的同时,统筹分析了转化生物体的内部代谢与外在条件之间的关联,进而提出苹果酸生物转化研究的发展趋势:重点利用同步糖化发酵提高转化效率,改善细胞耐受性与适应性,并通过提高菌株的五和六碳共发酵、碳化固定及控制能量平衡能力来提升苹果酸产量。
关键词:  苹果酸  生物质糖  食品酸味剂  高价值化学品  生物炼制
DOI:10.3969/j.issn.2095-6002.2019.02.001
投稿时间:2018-11-29
基金项目:
Progress for Bio-Refinery of Malic Acid
JIANG Shaotong,LI Xingjiang
(Key Laboratory for Agricultural Products Processing of Anhui Province/School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China)
Abstract:
Being a top bio-derived value added chemical, malic acid is used widely in various industries including chemical engineering, food, and pharmaceutical. It is of great significance to produce malic acid by converting sustainable cellulosic raw materials. This review has introduced and summarized the malic acid bio-refinery process, which was inoculating the fermented raw materials, analyzing the main metabolic pathways of the fermented raw materials, identifying the key enzymes for malic acid production, and determining the malic acid metabolism improvement strategy. At the same time as the technical summary, the correlation between the internal metabolism of the transformed organism and the external conditions was analyzed, and the forward trend of malic acid biotransformation was proposed. The forward trend was simultaneous of saccharification and fermentation processes to improve transformation efficiency, improving and enhancing cell tolerances and fermentation adaptabilities, promoting co-fermentation of five-carbon sugars and six-carbon sugars, decreasing greenhouse effect and controlling energy balance. This review was expected to provide meaningful insight to the development of the malic acid bio-refinery industry.
Key words:  malic acid  biomass sugars  sour agents  valued chemicals  bio-refinery